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KMID : 0383119630110010023
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Journal of Aerospace Medicine
1963 Volume.11 No. 1 p.23 ~ p.31
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Effect of Acute Hypoxia Upon the Total Circulating Blood Volume and Tissue Fluid Volume
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Abstract
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The living body, exposed to hypoxic condition, usually shows various physiological changes.
Much of the discussion has been done in the effort to. evaluate the physiological significances of
these changes. As long as the changes of the total circulating blood volume and tissue fluid
volume are concerned, there are no unanimous and decisive conclusions. Author attemped this experiment to follow up the real pattern of the changes and the physiological significances on this subject. The experimental group was exposed to simulated altitude chamber for 6 -hours at the altitude of 22, 000 feet (67 mmHg oxygen tension) and the control group was maintained for the same period of hours at sea level. 30 albino rats were used in each group. The total circulating blood and plasma volume, hematocrit ratio, extracellular fluid volume, plasma sodium and potassium concentration and water contents of tissues and organs were measured at the end of the exposure to -the hypoxic condition and to the sea level condition.
1) In the case of acute hypoxia, each circulating.. blood volume, plasma volume and the extracellular fluid volume showed an increase of 39.8%, 39.5%and 32.2 %, respectively.
2) Average´ hematocrit ratio was reduced by 1.3 %,but the increase of total´ volume of blood´ corpuscles could be defined relating to the resultant plasma volume increase
3) Plasma sodium concentration was increased by 5.8 rnEq/L on an average.
4) Tissue and organ water contents were reduced in the liver and increased in the plasma, muscle and skin.
5) potassium contents in the plasma showed no definite changes.
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